Which statement best describes the pattern of multiple sclerosis?

Which statement best describes the pattern of multiple sclerosis?

• A. S/sx are variable, asymmetric due to demyelination; patterns of exacerbation and remission.
• B. MS presents as a single, unchanging deficit in most patients.
• C. MS only affects motor function.
• D. MS is solely a demyelinating disease of the peripheral nerves.

Answer: (A)

The pattern tested here is that multiple sclerosis produces variable, focal neurologic deficits due to demyelination of the central nervous system, with episodes of worsening and partial recovery. In MS, the immune system attacks myelin in the brain and spinal cord, creating patchy areas of damage called plaques. Because these plaques can form anywhere along CNS pathways, the signs and symptoms differ from person to person and can be asymmetric—depending on which tracts are affected. People often experience relapses, where new or worsening symptoms appear, followed by periods of remission where some or all symptoms improve. Over time, the disease may evolve, but the hallmark is this relapsing-remitting pattern with a broad and variable set of neurologic manifestations. It is a central nervous system demyelinating disease, not a peripheral nerve problem, and it does not limit itself to motor function.

The pattern tested here is that multiple sclerosis produces variable, focal neurologic deficits due to demyelination of the central nervous system, with episodes of worsening and partial recovery. In MS, the immune system attacks myelin in the brain and spinal cord, creating patchy areas of damage called plaques. Because these plaques can form anywhere along CNS pathways, the signs and symptoms differ from person to person and can be asymmetric—depending on which tracts are affected. People often experience relapses, where new or worsening symptoms appear, followed by periods of remission where some or all symptoms improve. Over time, the disease may evolve, but the hallmark is this relapsing-remitting pattern with a broad and variable set of neurologic manifestations. It is a central nervous system demyelinating disease, not a peripheral nerve problem, and it does not limit itself to motor function.